CBD Oil Dose For Neuropathic Pain

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Learn more about how to figure out the right CBD dosage for your pain and other symptoms when there’s not definitive dosing information or research. Research has shown CBD alleviates neuropathic pain that didn’t respond to conventional treatment. View the best CBD oils for nerve pain.

CBD Dosage: What’s the Right Dose of CBD for Pain Relief?

Take a look at the label on any over-the-counter pain reliever and you can easily figure out how much you’re supposed to take for your symptoms. Finding the right dose of cannabidiol (CBD) for pain relief, however, isn’t that simple.

Enthusiasts rave about CBD’s potential to ease pain, reduce inflammation, relieve anxiety and promote sleep. However, there’s no conclusive research about just how much CBD a person needs to take in order to experience benefits.

There are very few human studies on CBD, and those that have been done include doses that are all over the map: In some studies, patients used 5 mg of CBD; in others, they took as much as 600 mg. To further add to the confusion, CBD comes in a number of forms — oils and tinctures, creams and lotions, pills, vaping, and edibles — and each one has differences in terms of bioavailability (the percent of active ingredient that gets into your bloodstream).

“There are no standard doses for patients,” says Rachna Patel, DO, a physician who does consultations about medical marijuana and CBD and sells her own line of CBD products. “Ultimately, it’s trial and error, but you have to go about it in a methodical way.”

Here are some tips to guide you on how to find the right CBD dosage for your pain relief and other symptoms.

1. Work with an expert

Many factors, such as your body mass index (BMI), specific health condition(s) you have, medications you take, your health history, and the form of CBD you plan to use can influence how much CBD you may need to treat your symptoms. Although CBD is different than medical marijuana — which contains CBD as well as THC, an intoxicating ingredient — a doctor who’s well-versed in cannabis (marijuana) is probably the best person to help you help you sort it out.

“I wouldn’t recommend starting CBD without the supervision of a physician,” says Dr. Patel, author of The CBD Solution. “Many times people purchase a CBD product, try a dose that that doesn’t work for them, switch products and spin their wheels. Or, worse, they develop side effects.”

Ask your rheumatologist or primary care provider to recommend an expert, or find an expert near you by searching the directory of members of the Society of Cannabis Clinicians or the database maintained by your state’s medical marijuana program (if it has one).

2. Do some math

Let’s say you and your doctor settle on a dose of 30 mg of CBD per day. Now what? The answer depends on which form of CBD you take.

Figuring out how much CBD is in capsules or gummies is simple — just read the supplement facts section on the label. (If it says 10 mg of CBD per capsule, you’d take three capsules to get your 30 mg of CBD a day.)

Oils and tinctures can be trickier because the packaging often states the amount of CBD in the entire bottle, not in a dropper. This calculator can help you figure out how many drops you need based on the strength of the product.

When it comes to CBD in topical form (creams, lotions, and salves), you’ll probably see the total amount of CBD in the container listed on the label. You’ll then have to divide that total by the number of millimeters in the package to determine how much is in each milliliter. For example, if you have a 50 ml jar of salve that contains 200 mg of CBD, there’s 4 mg per ml. You should then use a metric measuring spoon to scoop out 7.5 ml to get a 30 mg dose of CBD.

3. Expect some trial and error

No two patients respond to CBD in the same way. You and your doctor will probably need to adjust the dose either up or down until you hit the right balance of benefits without side effects. “A lot of it depends on your biochemistry and the way your liver breaks down these chemicals. There’s a wide variety of factors that come into play,” says Dr. Patel.

It can take a little while to get it right, so be patient. Many people do not see a difference in symptoms after one or two doses of CBD. It can take up to eight weeks of regular use to feel an impact, says Bridget Seritt, co-founder of the Canna-Patient Resource Connection, a Colorado-based organization that is working to protect patient rights and end stigma against those who choose cannabis as medicine.

4. If you have side effects, stop or lower the dose

CBD won’t get you high the way that cannabis with THC can, but it may still cause side effects. “The most common side effects are fatigue and lethargy, and in rare cases diarrhea,” says Dr. Patel, who notes that CBD that’s taken topically less commonly causes side effects. Topical CBD is best used to address pain in a single joint, rather than widespread pain, she adds.

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No matter which form of CBD you use, pay attention to how you feel. If you notice any negative side effects, stop or lower the dose and consult your doctor.

Best CBD Oil For Nerve Pain: Benefits & Dosage For Neuropathic Pain

Only 40% to 60% of patients able to find partial relief from their symptoms with conventional treatments.

Recent evidence suggests CBD oil may be a powerful natural treatment option for nerve-related pain.

Learn how it works & how to use it.

Article By

The human body is full of sensors leading to the brain. They sense temperature, touch, and tissue damage, and relay that information back to the brain for processing.

Neuropathic pain can be the result of damage to the nerves or pain sensors.

Learn what makes CBD so useful for treating neuropathic pain, how to use it effectively, and what other measures you can do to get the best chances of finding relief from your pain.

So, without further ado, let’s get into it.

MEDICALLY REVIEWED BY

Updated on October 20, 2021

Table of Contents
  • Can CBD Oil Help With Neuropathic (Nerve) Pain?
  • What is a Spinal Cord Injury?
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Can CBD Oil Help With Neuropathic (Nerve) Pain?

CBD and other cannabinoids offer relief from various causes of neuropathic pain in humans [2, 3].

It offers most of these benefits through its ability to interact with the endocannabinoid system (ECS).

The ECS consists of a series of receptors and eicosanoids (called endocannabinoids) that regulate homeostasis (balance) throughout the body. There are endocannabinoid receptors found on virtually every organ in the human body, with the highest concentration in the central nervous system.

The endocannabinoid system functions like “read receipts” used in text messages.

When the nerves send a message, the receiving nerve cell uses the endocannabinoid system to tell the sending nerve that the message was received.

This system keeps the entire nervous system in constant feedback with itself and prevents sending the same message more than once — which is essentially what happens when we experience neuropathic pain.

CBD also supports nerve pain by reducing inflammation, activating the vanilloid pain receptors, and alleviating many of the common side effects of nerve pain.

The benefits of CBD oil for neuropathic pain include:
  • Protects the nerve cells & brain
  • Supports nerve cell regeneration
  • Blocks pain transmission
  • Regulates electrical activity in the brain
  • Alleviates anxiety & depression
  • Supports sleep

What’s The Effective Dose of CBD For Neuropathic Pain?

When it comes to treating neuropathic pain — a notoriously difficult type of pain to alleviate — a higher strength of CBD is generally recommended. Most of the research showing benefits from CBD noted an abnormally large dose of the compound to achieve this success.

For this reason, it’s a good idea to work out the dose yourself to find out what’s best for you and your symptoms.

You can use our CBD oil dosage calculator to find the best dose based on your weight and desired level of effects.

Start small and increase the dose every day until you either experience relief from symptoms — meaning you’ve found your dose — or experience side effects. If you experience side effects, you may need to dial the dose back to the last side-effect-free dose.

If you’re still not getting any reduction in pain symptoms with this dose, you may need to combine CBD with other forms of pain management — after consulting with a doctor, of course.

CBD Dosage Calculator

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What Are The Side-Effects of CBD?

Although CBD has been proven to be highly safe many times over, it’s important to know about the potential side effects it may produce.

Everybody is different, and what works for one person doesn’t always work the same way for another.

Here are some of the most common side-effects of CBD:

Which Type of CBD Should I Use?

CBD comes in all different forms — not all are going to work for every condition.

1. CBD Oils & Tinctures

CBD oils and tinctures provide the easiest methods of taking CBD. All you need to do is measure out the desired dose (more on this later) and pop it into your mouth. You can choose to hold the oil/tincture under your tongue for faster absorption or swallow it right away — both will work well.

2. CBD Capsules

CBD capsules are another excellent dosing option you can employ. Capsules are small and easy to carry, deliver standardized CBD doses, and have great bioavailability. They’re also an excellent option for people who don’t want to taste the CBD oil — which can have an earthy, undesirable taste in some cases.

3. Topical CBD Products

Topical CBD is another good option, but only if the source of your neuropathic pain is close to the surface of the skin. It’s recommended that you use it alongside internal forms of CBD, such as capsules, edibles, or oils. This is because the cannabinoids in topical CBD products won’t reach the spinal cord and brain where most of the pain relief comes from when treating neuropathic pain.

4. CBD Edibles

CBD Edibles, including gummies or baked goods, are certainly a fun way of taking CBD — but they’re often inconsistent with dosing (with the exception of gummies). The dosages listed are estimates, and the actual CBD content inside can vary significantly.

For this reason, we don’t recommend relying on CBD edibles as your everyday maintenance dose of CBD for neuropathic pain.

What is Neuropathic Pain?

Neuropathic pain is a type of pain involving damage to or dysfunction of the nerves and somatic sensors found throughout the body.

Any damage to or dysfunction of the nerves and sensory tissues can send pain signals to the brain. These signals warn the body of real damage or dysfunction, but they can also be caused by false messages sent to the brain.

These messages warn the brain of damage that may or may not exist. This makes neuropathic pain difficult to treat, especially when the underlying cause can’t be identified.

1. Central Neuropathic Pain

The central nervous system is any part of the nervous system inside the brain and spinal cord. This is separated from the peripheral nervous system by a semipermeable barrier called the blood-brain barrier.

Central neuropathic pain, therefore, involves pain originating from nerves located inside the central nervous system.

It’s caused by conditions such as:

2. Peripheral Neuropathic Pain

The peripheral nervous system involves any part of the nervous system outside of the brain and spinal cord. This includes all the nerves in the limbs, abdominal cavity, legs, and face.

Often, when a nerve becomes damaged, the repair process may not go as planned. Instead of returning the nerve to the way it was before the damage, the nerve becomes unusually sensitive and will send pain signals to the brain when it shouldn’t.

The original damage can happen from many different causes, primarily traumatic injuries or specific viruses that target the nerve cells directly — such as herpes virus or shingles.

This type of pain is caused by conditions such as:

3. Mixed — Peripheral and Central Neuropathic Pain

Mixed neuropathic pain involves pain stemming from nerves found both inside the central nervous system and inside the peripheral nervous system.

Causes for mixed neuropathic pain include:

  • Cancer
  • Chemotherapy treatments
  • HIV and other viral infections
  • Heavy metal toxicity

What Are The Causes of Neuropathic (Nerve) Pain?

Neuropathic pain is caused by damage or dysfunction of the nerve cells. There are many causes for nerve damage in the body, such as:

Treatments for Neuropathic Pain

  • Antidepressants (SSRIs, SNRIs, and tricyclic antidepressants)
  • Opiate pain medications (morphine, fentanyl, tramadol, and methadone)
  • Surgical nerve blocks (severe cases only)
  • Capsaicin
  • Topical analgesics (lidocaine)

CBD For Spinal Cord Injury

Spinal cord injuries can have debilitating and life-altering consequences. Injuries can cause varying levels of paralysis, spasticity, loss of sensation, muscle weakness, and nerve pain that can persist for the rest of that person’s life.

There are some treatments available for this condition, most of which are supportive — helping those affected manage pain, depression, and other side-effects of the condition.

CBD cannot cure a spinal cord injury — however, it does likely offer a great deal of support for those affected by managing symptoms and promoting the repair of nerve cells in the damaged areas of the spinal cord.

There’s also some indication that CBD can support the recovery process — lowering the severity of side effects and improving motor function in the affected nerves [5].

The Benefits of CBD Oil For Spinal Cord Injury Includes:
  • Managing chronic pain
  • Relieving symptoms of mild to moderate depression
  • Adjunctive treatment to prevent antibiotic resistance during lung infection
  • Alleviating insomnia
  • Promoting nerve regeneration
  • Possibly reducing the extent of nerve damage from the incident

What is a Spinal Cord Injury?

The spinal cord is an extension of the brain. It contains high concentrations of nerve cell tracts that send and receive messages between the body and the brain. Any damage to the spinal cord can result in serious consequences, including paralysis, spasms, neuropathic pain, or loss of organ function.

The spinal cord contains millions of nerve “intersections” that distribute signals to every part of the body. The area of the spinal cord that is damaged will determine what side-effects develop and where.

For example, if the region of the spine containing the nerves that control leg muscles is damaged, it means that there will be a weakness or complete loss of function in those muscles and sensory deficits in one or both legs.

Spinal Cord Injury Symptoms
Types of Spinal Cord Injury

Depending on how severe the injury is, there are three main classifications that doctors use to describe the condition:

  1. Incomplete spinal cord injury — involves damage that hasn’t completely inhibited nerve transmission past the site of injury.
  2. Complete spinal cord injury — damage to the spinal cord is severe enough that no nerve signals can pass across the site of injury.
  3. Brown Séquard Syndrome— damage to exactly one half section of the cord, either left or right hemisection.

There are also several other types of spinal cord injury such as dorsal column lesion, irregular lesions, small or large central lesion, tumor of the dorsal root, or tumor of the meninges or bone.

The Location of the Spinal Cord Injury Matters

Nerves leave the brain and head down the spinal cord in bundles and pairs. They branch off at various points along the way to go to their target organs, and some tracts will cross sides.

The location of the damage to the spinal cord will determine which areas of the body are affected.

Complete damage of the spinal cord will prevent all nerves below the damaged point to stop receiving or sending messages. Therefore, to classify the level of injury, doctors will assess the lowest levels of different sensations and functions of the nerves in the spinal cord.

There are four main divisions of the spinal cord — organized according to the vertebral column. The vertebral column starts at one at the base of the skull and goes all the way to the coccyx. The spinal cord, in fact, actually ends between vertebrae L1-L2, and is followed by a bundle of nerves called the cauda equina the rest of the way down.

Causes of Spinal Cord Injuries

What the Research Says

In 2012, researchers conducted a study on the use of CBD for spinal cord injuries in rats [5]. Rats were either placed in the treatment group and given CBD, or into the control group where no treatment was given. At the end of the six-day study, rats in the CBD treatment group had significant improvements in motor function and reduced injury side-effects than rats in the no-treatment group. Therefore, the researchers conducting this study concluded that CBD might be a useful treatment option for spinal cord lesions (injuries).

Another study used a survey that was handed out to 10 spinal cord injury patients at the Spinal Cord Injury ward of the Miami V.A. Hospital who were using marijuana to treat their symptoms. The survey was kept confidential and involved questions about the most common symptoms of the condition and how marijuana use affected them.

Results of This Survey Listed:
Symptoms Made Worse Made Better No Effect Distraction Not Applicable
Phantom Pain 1 4 2 2 1
Muscle Spasticity 5 3 2
Bladder Spasms 1 1 7 1
Urinary Retention 2 8 1
Headaches 5 4 1

THC has also offered benefits for spinal cord injuries. For this reason, a full-spectrum cannabis extract containing both CBD and THC is considered the best option.

Potential Benefits of THC for Spinal Cord Injuries
  • Reduces muscle spasms involved with spinal cord injuries [6]
  • Improves bladder control in spinal cord injuries [7]
  • Reduces pain associated with spinal cord injuries [8]

THC remains illegal throughout most of the world, so it may be difficult to find products containing more than 0.3% THC concentration. Further robust studies will be needed to better characterize standard effects and determine efficacy.

Key Takeaways: Does CBD Oil Work For Neuropathic Pain?

The causes of neuropathic pain can range from neurological issues such as multiple sclerosis or a stroke to nutritional deficiencies and diabetes.

No matter what’s causing neuropathic pain, the benefits of CBD remain much the same.

CBD can support neuropathic pain in the following ways:

  • Increases anandamide levels
  • Activates the vanilloid receptors
  • Inhibits inflammation that may be causing neuropathic pain
  • Mildly activates the opioid receptors in the spinal cord and brain

When it comes to treating neuropathic pain, a higher dose is usually recommended — however, this can vary from person to person. Whenever using CBD for the first time, it’s wise to start low and increase slowly over time until you receive the benefits you’re looking for.

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