CBD Oil For Depression


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Besides its wellness benefits, research is assessing CBD oil’s effectiveness in easing the symptoms of depression. Here’s what we know so far. Learn more! Some research suggests that CBD can help with depression and anxiety and provide pain relief. And, because hemp-derived CBD is legal in all 50 states, it’s never been easier to give it a try yourself Choose from our range of CBD Oil For Depression – Benefits of CBD products. Shop now and get Free UK Delivery on orders over £30+. Switch to our Vape Refills today!

Could CBD Oil Ease Symptoms Of Depression?

Research into the health benefits of CBD products is moving beyond anecdotal evidence. An increasing number of scientific studies are being conducted in order to understand its effectiveness as a natural therapeutic aid. In 2020, a study from the University of Auckland sought to understand the effects of CBD being included in the treatment of participants diagnosed with depression. An audit of 400 patients showed a significant improvement of symptoms in participants who received CBD.

Anxiety and depression often exist together. A person diagnosed with depression is likely to also exhibit some symptoms of anxiety and vice-versa. In other words, they are comorbid. So, reducing symptoms of anxiety will likely have a positive impact on someone’s depression too. Although research is still at a very nascent stage, there have been several studies that showed the effectiveness of CBD in reducing the physiological symptoms of anxiety.

How Can You Start Using CBD to Treat Depression?

For non-pharmacological depression treatment, CBD oil is available in a number of different forms. There are oils and capsules to choose from depending on the strength and dosage of CBD you need. Each method of ingestion produces a different effect. For instance, if you choose to include it in your food, the effect will be milder but is likely to last longer.

CBD products are available through GPs and licenced clinics such as The Pain Clinic. We recommend that you consult a medical practitioner before including CBD in your treatment plan. A qualified practitioner will be able to assess whether CBD will help in your case and prescribe a dosage that would work for you.

CBD is processed differently by each person depending on their body composition. Although CBD has a high safety profile and is generally well-tolerated, some mild side effects have been observed.

How Can CBD Help Reduce Symptoms of Depression?

CBD is a naturally occurring chemical extracted from the cannabis plant. A common misconception is that CBD consumption comes with an accompanying ‘high’ that cannabis is infamous for. In fact, CBD or cannabidiol, does not have any psychoactive properties as it is devoid of THC which is responsible for this.

What CBD is able to do is interact and bind with various receptors in our body to create positive changes that we experience.

Serotonin, a.k.a. the happy hormone, has a big role to play in the state of your mental health. In fact, serotonin supplements are often part of the treatment plan for depression. CBD is able to activate serotonin receptors to help alleviate your state of mind.

Another hormone that plays a key part in affecting your mental health is cortisol. This ‘stress’ hormone pushes your body to stay alert. It is a crucial trigger of stress and CBD oil for anxiety. When produced in excess, it can negatively impact your mental health. CBD is able to reduce the production of cortisol and consequently, bring down its stressful effects.

Chronic pain and depression have strong links to one another. We don’t often connect alterations in our mental health to the development of fairly common issues like sciatica or lower back pain. However, chronic pain can have a debilitating effect on your mental health. CBD has been used to alleviate some of this pain and as a result, improve general mental well-being as well as sleep cycles.

CBD Oil May Help Alleviate Your Depression

There are a number of factors in play with complex mental health conditions like depression and anxiety. There is rarely one pill that can address all its facets, and therapy is key to understanding how to cope. A common misconception about mental health conditions is that they reside solely in the mind with no underlying physiological basis. When in fact, hormonal imbalances, the state of your physical health and experiences with chronic pain (among other factors) all impact mental health. As research progresses, the role that CBD is poised to play is to address several of these physiological symptoms in the hope that it will put you in a better position to create a balance in your mental well-being.

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10 Best CBD Oils For Anxiety And Depression

Especially after the horrors of the pandemic, more and more Americans are looking for ways to treat stress healthily. But, for some, it can be more than stress. According to the National Institute for Mental Health, an estimated 21 million adults in the United States had at least one major depressive episode. In addition, an estimated 19.1% of U.S. adults had any anxiety disorder in the past year. These are serious medical conditions, so if you believe you or someone you know is experiencing anxiety or depression, talk to a doctor immediately and consult with them before taking any CBD products. Some research suggests that CBD can help with depression and anxiety and provide pain relief. And, because hemp-derived CBD is legal in all 50 states, it’s never been easier to give it a try yourself. But not all CBD is created equally. Keep reading for 10 CBD oils that offer various options to help combat stress, anxiety, and whatever else is ailing you.

Penguin CBD Oil

Penguin’s all-natural CBD oil comes from made Oregon-grown hemp. It’s broad-spectrum, meaning that most of the whole natural goodness of the plant is kept during the extraction process. It’s THC-free, so legal, and available all across the country. It comes in five strengths, ranging from 250mg to 5000mg in each bottle, allowing you to customize your use. Plus, there are five flavors to choose from: all-natural, mint, citrus, strawberry, and cookies & cream.

Everest Full Spectrum Oil

Everest diligently controls each element of the production cycle, from selecting the seeds to carefully nurturing the soil the all-natural hemp is grown in. They use non-GMO stock and avoid the use of pesticides. Their yummy blueberry oil contains both CBD and THC, which is excellent news for those who like a little euphoria, but as a result, this product is only available in fully legal states.


Depression and anxiety are two of the most common mental issues that most of us will face, and left untreated can have a huge impact on our lives.

With a growing awareness over the last 30 years on the importance of mental health, and an increasing prevalence of anxiety disorders, it is becoming ever more important to find ways of improving our mental health.

Depression can be caused by a number of things, from a stressful or traumatic life event, to abnormal neurotransmitter activity. In the case of abnormal neurotransmitter activity, prescription medications can be used to adjust the balance in the brain, but no prescription medication can rectify a traumatic life event.

Whatever the cause, there is a growing body of evidence for the use of CBD products in a number of medical settings, including treating anxiety.


Cannabidiol CBD is one of many chemicals found in the cannabis plant, which is why it is known as a ‘cannabinoid’. CBD Oils can be made from one of three specific types of CBD:

  • CBD Isolate – this is just cannabidiol without any other compounds.
  • Broad Spectrum CBD – this is CBD plus the flavonoids and terpenes found in the cannabis plant.
  • Full Spectrum CBD – this is CBD plus the flavonoids and terpenes found in the cannabis plant and the other main cannabinoid, tetrahydrocannabinol- or ‘THC’ for short.

In the cannabis plant, the levels of CBD and levels of THC are inversely proportional – this means that cannabis plants with high levels of THC naturally have low levels of CBD. Plants with higher levels of CBD naturally have lower levels of THC, and if the level of THC is below 0.3%, then the plant is classified as a hemp plant.

This is why you will see many CBD products are ‘hemp derived’ – the cannabis plants harvested to extract the CBD have levels lower than 0.3% THC, and are therefore hemp plants!

Each type of CBD product includes different amounts of the other chemicals found in the hemp plant, with CBD isolate being the only one that doesn’t include any extras from the plant – literally just the CBD.

Broad spectrum CBD contains these extras found in the plant to benefit from the entourage effect. This is the observed action of the other chemicals in the plant working in synergy with the CBD to improve its effect. The only thing it doesn’t include is the THC – therefore there is no risk of any intoxication.

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Full spectrum CBD is the only form that includes that last cannabinoid – THC – in the product. The levels of THC should be too low to cause intoxication, but there have been instances of Full Spectrum CBD products containing higher levels of THC than stated on the packaging, causing them to be removed from sale in the UK.


The health benefits of CBD oils are wide ranging because it acts on the human ‘endocannabinoid system’ – so called because it uses cannabinoid-like chemicals – which plays a huge role in how our body communicates with the variety of systems found in us: from the immune system to the nervous system.

The role of the endocannabinoid system appears to be connected to the regulation of our functions to ‘eat, sleep, relax, forget and protect’ – all pretty essential functions, I’m sure you’d agree!

While more studies are needed to confirm the mechanisms at work, the evidence so far indicates that the presence of CBD could improve many of the functions related to the endocannabinoid system.


Using CBD for depression could well reap beneficial results. As for why, there are a few proposed mechanisms, and it could be that one main mechanism is doing the most of the work, or it could be the combination of mechanisms working together produce the effect that some users see when they take CBD.

What causes depression?

As previously mentioned, there isn’t necessarily a single cause of depression. It is thought low levels of neurotransmitters could be the culprit; it could be down to disrupted communication between parts of the brain responsible for mood, like the prefrontal cortex and hippocampus. It could also be the loss of a loved one, or experiencing a traumatic event.

This wide range of causes can make tackling the root of the problem more challenging, and in some cases, impossible. That’s where we need all the help we can get to improve our quality of life, with a view to getting out of depression, if possible.

Why is CBD oil recommended for depression?

Using CBD to try and tackle depression could work for a number of reasons. There is a lot of anecdotal evidence; stories from CBD users who have seen improvements in their depression are a powerful recommendation, but that doesn’t guarantee every individual will see improvements from using CBD.

How does CBD oil help depression?

The presence of CBD reduces the breakdown of an endocannabinoid known as ‘anandamide’ – it is nicknamed the bliss chemical and is associated with feelings of joy and happiness. By reducing the breakdown of anandamide, more of it will be present, potentially resulting in improved mood.

Another mechanism may be low levels of neurotransmitters causing an impaired communication between the prefrontal cortex and hippocampus. One study found that stimulating the endocannabinoid system using CBD regulates activity in areas related to emotional processing.

A separate proposed method by which CBD could help sufferers of depression and relieve symptoms of anxiety is the regulation of a neurotransmitter known as GABA.

This neurotransmitter encourages the slowing down or stopping of neurons firing, and anxiety and stress can cause levels of GABA to decrease, resulting in over-firing neurons. It is thought that CBD can improve levels of GABA, resulting in a return to normal neuron function.

GABA is tied in with anxiety and panic attacks too, with increased GABA function resulting in reduced anxiety. This illustrates another function of CBD that could be beneficial to sufferers of anxiety and panic attacks.

How to use CBD oil for depression?

When it comes to dosing CBD for depression, or any other reason, you should start on a low dose and increase it if necessary. This means, for example, taking three drops of low strength CBD oral drops as a single dose, twice per day. This will give you a dose of 7.5mg of CBD per session, or a daily dose of 15mg.

The important thing to keep in mind when you buy CBD for depression is that it isn’t applied to the skin – this means no topical creams or balms – simply because the CBD doesn’t make it into the bloodstream this way. Using edible CBD, CBD oral drops or CBD vape liquid will get the CBD into the blood, and therefore to the brain.

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The matter of which type of CBD to go for to see the most benefits is another good question. Full spectrum CBD will see the entourage effect taking place, but if the source is untrustworthy, you could end up ingesting more THC than you want because they haven’t accurately labelled the product.

Why is this a bad thing? Well for most people this is unlikely to be too much of an issue – but for people competing in sports at a high level, even low levels of THC could show up on a drug test, potentially leading to disqualification from competition.

CBD Isolate is a safe bet, in comparison, but doesn’t benefit from the other compounds in the cannabis plant, so no entourage effect is present in CBD isolate products. Therefore, the middle ground that benefits from the entourage effect without risk of exposure to THC are broad spectrum CBD products!


According to the World Health Organization, CBD exhibits no abuse potential and does not appear to cause harm in the long term. This is exemplified by the CBD medication Epidiolex, which is administered to children in the hundreds of micrograms per dose to treat rare forms of epilepsy.

That doesn’t mean you should start giving yourself a dose of that size – you are more likely to experience side effects at higher doses, and small doses are sufficient for many people to start seeing improvements – dosing more that you need is just going to be an expensive waste of your CBD, and could result in feeling a bit off kilter!


In short – yes, CBD is legal in the UK. For more information on the legality of CBD, check out our blog article explaining the legal state of CBD in the UK.


If you’ve read this far, then there’s a good chance that you are considering CBD oil for anxiety and/or depression, either for yourself or someone you know. Before making the leap, there are several things to consider.

CBD has the ability to impact how the liver processes medications, so if you are currently using a prescribed medication you should consult your doctor before taking CBD to avoid negative drug interactions.

Make sure you choose the correct type of CBD for your needs, and avoid products with any amount of THC if you are subject to drug testing. Remember – if you want the maximum benefit from CBD without any THC, it’s the broad spectrum CBD products you want!

When you start on CBD, make sure to start on a low strength product, or in the case of edibles, keep your consumption low. Higher doses of CBD are more likely to lead to side effects, and these can include drowsiness, fatigue, dry mouth, diarrhoea and reduced appetite.

Starting on a low dose means you can gradually increase the intake of CBD until you see an effect, helping you work out your very own effective dose!

Finally, buying from a reputable, trusted source is important for being able to trust the contents on the product packaging. One particular brand was taken off the shelves because the level of THC was far above the legal level, as well as the level stated on the packaging.

At SMOKO, you can see the certificates from the third party testing for our CBD products online, so you know you can buy SMOKO CBD products with absolute confidence!


There is still much to be learned from studying the interactions of CBD in the body, and while much of the evidence needs to be corroborated in further studies, the outlook is very promising for the future of CBD in the use of a number of ailments.

If you are considering using CBD to help with depression, anxiety, or any number of other issues, then check out the SMOKO CBD range for broad spectrum CBD products that you can trust.

Made here, in the UK, from CBD cryogenically extracted from responsibly farmed, organically grown cannabis sativa L plants in Oregon, USA – the range is vegan friendly and gluten free, so take advantage of our limited time offer and see if CBD can help you – at a great price!

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