Pharmacist’s Guide to CBD Oil ABSTRACT: Cannabidiol (CBD) is becoming more prevalent, and pharmacists must be knowledgeable about these products in order to counsel patients effectively. CBD In the world of CBD, one can get lost in a sea of acronyms and jargon. Here, a beginner-friendly guide to shopping for CBD oils, tinctures, serums and creams. Beginner’s Guide to CBD Project CBD has created a beginner’s guide to address key questions people have when starting CBD and cannabis therapy. Project CBD was established in 2010 by
Pharmacist’s Guide to CBD Oil
ABSTRACT: Cannabidiol (CBD) is becoming more prevalent, and pharmacists must be knowledgeable about these products in order to counsel patients effectively. CBD laws and regulations are determined at the state level in the United States. Non–FDA-approved CBD products are not regulated and may contain harmful chemicals. Pharmacists must counsel patients on where and how to obtain products and to check the amount of CBD and delta-9-tetrahydrocannabinol in the product. CBD has numerous drug interactions that should be evaluated by a pharmacist. CBD is most promising for treatment-resistant seizures, and more research is necessary to evaluate its use for other indications. Sativex is currently being investigated in the U.S. for treatment of spasticity associated with multiple sclerosis and schizophrenia. In general, more studies of CBD are needed.
Cannabidiol (CBD) is gaining popularity across the United States. Pharmacists must be able to answer patients’ questions about CBD and make recommendations. This article will provide specific information about CBD, including laws, how to select a non–FDA-approved CBD product, indications for use, side effects and warnings, drug interactions, dosing and directions, pharmacokinetics, and the future of CBD oil. After reading this article, pharmacists should feel confident about counseling patients about CBD and recommending CBD products.
Laws Concerning CBD
CBD was first isolated from the Cannabis sativa plant in the 1930s. CBD is a nonpsychoactive part of the plant, whereas delta-9-tetrahydrocannabinol (THC) is the major psychoactive part of the plant. In the 1970s, researchers evaluated CBD as a pharmacologic agent. 1 Epidiolex, a 100 mg/mL oral solution with less than 0.01% THC, became the first FDA-approved CBD-containing drug in June 2018. 2 The drug is Schedule V and indicated only as an anticonvulsant for Lennox-Gastaut syndrome or Dravet syndrome in patients aged 2 years and older. 3
In December 2018, the Agriculture Improvement Act, which removed hemp from Drug Enforcement Administration (DEA) regulation as a controlled substance, was passed and signed into U.S. law. Hemp is defined as a cannabis plant that contains no more than 0.3% THC. (In contrast, marijuana has a higher THC.) Hemp is now regulated by the U.S. Department of Agriculture and is legal in all 50 states. Laws and restrictions regarding the selling of hemp products vary by state, making it questionable to travel with CBD products. 2
U.S. laws and regulations concerning CBD are determined at the state level. Currently, 33 states have legalized CBD use for medical purposes, and 10 states (Alaska, California, Colorado, Maine, Massachusetts, Michigan, Nevada, Oregon, Vermont, and Washington) and the District of Columbia have legalized marijuana for recreational use. In states such as New York, Minnesota, and Connecticut, pharmacists are required to dispense the products in authorized dispensaries. Marijuana-derived CBD oil is still considered illegal under the Controlled Substances Act in accordance with the DEA’s classification of marijuana as a Schedule I substance. 2
Selecting a Non–FDA-Approved CBD Product
Pharmacists must educate patients about how to select an appropriate non–FDA-approved CBD product. These products are not tested for safety, efficacy, or quality. 4 The main concerns in picking a non–FDA-approved CBD product are that it may contain harmful chemicals and may not accurately list the correct amounts of CBD and THC it contains. These products could contain harmful contaminants (e.g., pesticides, heavy metals) or have high levels of THC, which would result in a positive urine drug test. 5 The patient should be advised to obtain CBD products from a medical dispensary because these products are regulated. The patient should also consider ordering products from states where CBD is legal because more testing is done in those states. When selecting a product, the patient should check the label to see if it lists the amount of CBD in each dose. 5,6 The manufacturer should provide a Certificate of Analysis, which shows an independent laboratory’s assessment of the product’s potency and the presence of contaminants. 5 When assessing quality, the patient should look for the Hemp Authority seal, which means that the product is legal and the manufacturer is adhering to quality standards. 7
Indications for CBD
As consumer demand in the U.S. has risen, along with the number of dispensaries, the number of studies addressing the therapeutic effects of CBD has increased. The studies performed, however, are insufficient; large randomized, placebo-controlled trials need to be conducted. CBD seems most promising for treatment-resistant seizures. There is limited evidence concerning the use of CBD for psychotic symptoms in Parkinson’s disease and for anxiety related to public speaking. CBD has not been proven effective for pain, nausea, or depression. 4 THC, conversely, is thought to be effective for these conditions because it has a different mechanism of action. THC activates the CB1 and CB2 receptors in the brain, and CBD does not. As mentioned previously, CBD does not have psychotropic effects and THC does. These differences are believed to account for the different uses of CBD and THC. 7,8
Patients with early-onset epilepsy who are resistant to conventional therapy may benefit from CBD oil. A trial that investigated the effect of CBD on drop seizures of Lennox-Gastaut syndrome found that CBD 10 mg/kg/day or 20 mg/kg/day, when added to conventional therapy, led to a greater reduction of drop seizures compared with placebo. 9 The most common adverse reactions were somnolence, decreased appetite, and diarrhea. Specific adverse events from CBD included elevated liver aminotransferase concentrations. 9
Clinical findings on the use of CBD oil in Parkinson’s disease (PD) remain unclear. Past studies have evaluated CBD’s efficacy in minimizing nonmotor symptoms of PD, such as cognitive deficits, sleep disturbances, psychosis, depression, and anxiety. 10 The neuroprotective properties of CBD have been studied in animals with PD, with results indicating that CBD appears to reduce psychotic symptoms. 11 Although patients with PD have reported fewer sleep disturbances as well as improvements in quality of life, treatment in humans requires further investigation on a larger scale, with longer durations and more standardized dosing. 12 Most studies have used combinations of CBD and THC extracts, including nabilone, a synthetic CB1 receptor agonist. CBD dosages of 150 mg/day for 4 weeks and titrated by 140 mg/week were found to be safe and well tolerated and did not worsen motor function. 10
More evidence is needed to support the use of CBD for anxiety. Studies have found that CBD 300 mg may be effective for anxiety related to public speaking, and doses of 400 mg to 600 mg may help patients with social anxiety disorder and public speaking–related anxiety. Studies are inconclusive concerning the utility of CBD for anxiety. 13
Side Effects and Warnings
Studies have reported various properties and potential benefits of CBD. Some undesired side effects of CBD use are decreased appetite, dry mouth, diarrhea, dizziness, drowsiness, fatigue, lightheadedness, orthostatic hypotension, psychomotor slowing, sedation, somnolence, weight loss, and increased risk of liver injury with dosages of 20 mg/kg/day or the use of clobazam or valproate. Monitoring of liver enzymes, weight, and cognitive function may be warranted. CBD can pass through the placenta, so it is recommended that CBD be avoided during pregnancy and while breastfeeding. Because CBD oils may contain trace amounts of THC, operating heavy machinery and driving should be avoided when treatment is initiated. 1
CBD is metabolized in the liver, mainly by CYP2C19, CYP3A4, and UGT. This can lead to interactions with prescription drugs, OTC medications, and herbal supplements. 1,14
The inhibition of CYP2C19 by CBD can increase levels of carisoprodol, citalopram, clopidogrel, diazepam, phenytoin, proton pump inhibitors (PPIs), valproic acid, and warfarin. As a strong CYP3A4 inducer, CBD may lessen the efficacy of amlodipine, atorvastatin, buprenorphine, bupropion, diltiazem, eplerenone, fentanyl, loperamide, midazolam, paclitaxel, pioglitazone, sildenafil, solifenacin, tamsulosin, testosterone, topiramate, zolpidem, and other 3A4 substrates. 7
More serious effects may occur with concomitant use of central nervous system depressants, such as barbiturates, benzodiazepines, fentanyl, morphine, and propofol. These effects are the result of the synergistic effects of sedation and hypnotic effects at high doses. Increased sedative effects may also be seen with herbal supplements, including kava, melatonin, S-adenosylmethionine, and St. John’s wort. 13,14
Other interactions to be aware of are presented in TABLE 1.
Dosing and Directions
In unregulated dispensaries, CBD oil sold comes in a sublingual formulation known as CBD tincture and is generally available in 30-mL bottles with dropper caps. 15 A bottle costs approximately $20. The concentration of the tincture ranges from about 1,500 mg to 3,000 mg per bottle. If a drop equals 0.05 mL, one bottle contains approximately 600 drops of CBD oil. Drops are usually placed under the tongue, and the patient should let the oil absorb into the lining of the mouth, without swallowing, for 30 seconds to 1 minute. Capsules and gummies are also available. 15
As noted earlier, Epidiolex (CBD) is an FDA-approved oral solution for treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome. The cost of Epidiolex is approximately $2,708 per month. It is supplied as 100 mL of solution containing CBD 100 mg/mL. For both indications, the initial starting dosage is 2.5 mg/kg orally twice daily for 1 week. The dosage may be titrated weekly in increments of 2.5 mg/kg twice daily to a maintenance dosage of 5 mg/kg twice daily. The maximum dosage is 10 mg/kg twice daily or 20 mg/kg/day. Gradual tapering is recommended when Epidiolex is discontinued. 3
Starting at a low dosage is recommended for elderly patients and patients with moderate or severe hepatic impairment. The dosage should be 1.25 mg/kg to 5 mg/kg twice daily or 0.5 mg/kg to 2 mg/kg twice daily, respectively. 3
CBD reaches its maximum concentration in 2.5 to 5 hours. High-calorie and high-fat meals can increase the maximum concentration of drug fivefold and the AUC fourfold. 14 Owing to the first-pass effect, CBD is poorly absorbed, with a bioavailability of 13% to 19%. Better bioavailability has been reported with inhaled CBD (11% to 45%). CBD is 94% protein bound; therefore, interactions may occur with other highly protein bound drugs or in patients who have abnormal albumin levels. The volume of distribution is 20,963 L to 42,849 L, meaning that the drug is largely distributed into the tissues. CBD is metabolized by the gut and primarily by the liver. Epidiolex has an active metabolite, 7-OH-CBD, and is a 2C19 and 3A4 substrate and inhibitor of 2C19, 1A2, UGT1A9, and UGT2B7. Its elimination half-life is 56 to 61 hours. CBD is excreted primarily in the feces and urine. 3
The Future of CBD
Sativex (nabiximols) is an oromucosal spray that contains CBD and THC in a 1:1 ratio. The active ingredients are absorbed sublingually or buccally. Sativex is currently under investigation in the U.S.; however, more than 25 countries worldwide have approved Sativex for the treatment of spasticity associated with multiple sclerosis. Sativex is also being researched for potential treatment of schizophrenia and other conditions. 16
The Pharmacist’s Role
Some pharmacists are hesitant to get involved with CBD. Prosecution by federal law could lead to severe consequences, including fines, imprisonment, or loss of DEA registration for pharmacies, ultimately stripping them of their ability to dispense controlled substances. If U.S. laws and regulations were more uniform across states, many of the concerns surrounding CBD would be eliminated. Until then, patients must use caution when selecting a product from an unregulated source because of the possibility of contamination and product misbranding. 17 Although more testing is needed, it is imperative for pharmacists to understand what to recommend to patients. Pharmacists should counsel patients on the risks and benefits of treatment. Patients who are are using CBD should be reminded to obtain the product from a reputable manufacturer. 17
Pharmacists need to keep abreast of current information on CBD in order to assist patients who are interested in using it. While most studies are inconclusive, there currently is enough information to effectively guide patients in choosing a treatment. CBD has the most evidence for treatment-resistant seizures; other indications need further study. Patients must be counseled to choose an appropriate product from a reputable source. CBD may be misbranded or contaminated with harmful chemicals. Pharmacists are uniquely positioned to assess the numerous potential drug interactions with CBD. New prescription CBD products are currently being investigated in the U.S.
A Beginners Guide To Shopping For CBD Oils, Tinctures, Serums And Candies
CBD or cannabidoils have become a hero ingredient for wellness products that help with pain, stress, . [+] anxiety and even skin breakouts.
The CBD culture, at least in the eyes of someone who knows zero, can be overwhelming. There’s the Full Spectrum variant. Then there’s broad spectrum and isolate. Some labels say they are cannabis derived, while others say they are hemp based. Then you come across its various forms—creams, tinctures, drinks and oils. They even have gummies, capsules and patches.
When I first started to look into CBD as a wellness product, I remember feeling lost in a sea of jargon. “Contains 0.2% THC,” read one label. Another stated: “With enhanced CBN with Terpenes.” I had no idea what these words meant and how they might affect my life.
CBD, or cannabidoil, has become a buzzword in wellness circles. This plant derivative found in the cannabis sativa or hemp plant, has gained traction for its ability to ease anxiety and depression. CBD is also often used to ease inflammation, muscle soreness and pains. As a beauty product, CBD face oils have become the hero of minimalist skincare routines. They address a wide range of concerns from acne to aging.
A friend of mine who convinced me to give CBD a try declared: “CBD helps me with everything. I’ve been sleeping better and consuming less gin since taking it. Even my dog takes CBD.” More than literature, available information or hype, it was her testimonial that had me sold.
FIRST THING’S FIRST: WILL IT GET ME HIGH?
The first question I asked before taking my first does was, “Will this get me high?” It’s not uncommon for first time users to confuse CBD with the marijuana they’ve come to know from naughty younger years. Although extracted from hemp or cannabis plants, CBD is isolated from psychoactive compounds (like THC) that effect the feeling of being “high. CBD, on its own or when derived from hemp, cannot not get you high. Instead, it helps alleviate anxiety, stress, pains and aches. This miracle ingredient also functions as an anti inflammatory.
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Cannabidoil is legal in some countries and states. In others, it remains prohibited or strictly regulated. When shopping for CBD online, check in first to see if this ingredient is allowed in your state or country of residence.
THE CBD FEELS—WHAT IT DOES, HOW IT FEELS, WHEN TO TAKE IT
When ingested as oils, gummies or infused drinks, CBD can benefit those who suffer from anxiety, depression or sleep problems. It also helps bring a sense of balance and focus especially on days that feel more like a roller coaster ride. When you need to feel a little more balanced or grounded, CBD does wonders in anchoring you throughout the day. It is also a soothing potion for winding down after a busy day.
COMMON GROUND’S WAKE/ 1000 MG CBD + CBG OIL
COMMON GROUND’S WAKE/ 1000 MG CBD + CBG OIL is a great way to start your day. It’s a lot like coffee served with doses of calm. Formulated so that you can use it any time of the day, WAKE is a “simple, clean and honest CBD + MCT Oil + Terpenes bland that give your body exactly what it needs.” As a beginner who is only starting to discover the transformative effects of this compound, I find one full dropper of WAKE in the morning helps to set the right mood. It helps keep me calm and focused especially when days you feel the chase of deadlines and follow up emails.
MATCHA UNION Full Spectrum 15% CBD Oil
If matcha is your beverage of choice, then MATCHA UNION’S new range of CBD FULL Spectrum Oils is your cup of tea. Formulated using hemp seed oil and cannabidoil sourced from organic farms in South of France, MATCHA UNION boasts “maximum anti inflammatory properties.” Cold pressing methods ensure that the brand’s formulas retain all the plant matter including chlorophyll and Terpenes, which are packed with health benefits. The brand’s blends are free from other carrier oils, making it uncompromisingly pure and potent. The brand’s founders explain: “We only use hemp oil and cannabidoil, which both come from the same plant, thus maximizing its benefits.” Match Union CBD is a great elixir to have on days when you feel particularly heavy or bloated. It is also a miracle worker for when you need to reconnect with your zen midday. On long days in front of the computer screen, a cup of ceremonial green matcha and CBD are instant mood boosters.
TRIP Elderflower and Mint CBD Drink
Sunset cocktails or happy hour has always been about a good bottle of wine or a refreshing G&T drink. It was only after trying TRIP’s CBD INFUSED DRINKS that I realized how much more delicious winding down can be. The UK-based wellness brand is all about harnessing calm and productivity—but with lots of flavor. By this, I mean both literally and figuratively. TRIP’s Best Selling Sparkling Drinks are delicious as they are beneficial for one’s overall wellness. They are formulated with L-Theanin to boost mood, chamomile to soothe as well as ginseng to help improve energy and focus. TRIP’s drinks can be enjoyed on its own or mixed with other spirits. Since opening my box of Trip Mixed Pack CBD Drinks, happy hour has become about sipping on a Gin and Trip to wind down. Trip Founder Olivia Ferdi shares: “What we’ve learnt is that CBD drinks have provided an alcohol alternative to many, as well as a functional option for a- home socializing, or reset through the working day. An after-work zoom drink is certainly made more relaxing with TRIP drinks! Our experience is that CBD is very much accepted by our target demographic of urban Gen Z and millenials. Especially as so many of them are looking for plant active, functional options instead of alcohol to help them unwind. The incredible thing about CBD is that it can support both mental and physical wellbeing – making it appealing across moments and different lifestyles.”
TRIP Orange Blossom CBD Oil
TRIP’s CBD Oils are also the most delicious and fragrant. It’s almost like having a calming candy. They come in two flavors—Orange Blossom and Wild Mint. There is also option to take the strong (1000MG) or original variant (300mg) which is recommended for first time users. Formulations from TRIP are blended with MCT Oil, natural adaptogens and chamomile to help establish a sense of balance. The team adds, “Our CBD is extracted from organically grown help, THC-free and third party lab tested to ensure the highest quality and purity.” I’ve had some of the deepest most restorative evenings with TRIP ORANGE BLOSSOM CBD OIL, waking up feeling fresh and recharged. It is definitely a bedside essential. Oliva shares insight for first time users of CBD: “I recommend checking for mg CBD per serving. When comparing products for strength (and price value) it can become a little overwhelming between brands and formats. Checking how much CBD is in a whole product can be helpful (rather than running comparisons of % concentration). Start with a lower daily dose, say 10-30 mg and see how you feel. Start to experiment with varied doses to obtain the desired effect (whether that’s a reset during work, or relaxing after work).”
SPERO CBD Whole Plant Extract Capsules and Tinctures
SPERO makes it easy and less intimidating for first time users to explore the world of CBD. Its product range is pretty straightforward. There are pure CBD capsules for easier consumption—no need for droppers or to measure dosage. Tinctures, of course, are also an option for a dose of tranquility and calm. All formulas from SPERO are eco-friendly, sustainably sourced and THC free. The company subscribes to a unique extraction process using CO2. The at SPERO explains: “Our products are crafted using Liquid Chromotography—a sophisticated purification process that cleanly separates CBD from THC with precision. Unlike distillation, it doesn’t leave behind residual compounds and solvents, only a potent and pure extract of broad-spectrum CBD oil, hempbased minor cannabidoids and terpenes.”
Their Pure CBD Tincture is a refreshing, zero-high, beginner-friendly blend. It is fast-acting and tastes a lot like your favorite candy. What makes this ideal for first time users is that each bottle comes with a pre-measured dropper (17mg per serving) for easy dosing. The company emphasizes, “We are committed to spreading a new standard of CBD wellness. each product is rigorously tested for potency, pesticides, microbials, heavy metals and solvents… so you get the good stuff and none of the bad.”
CBD FOR ACTIVE LIFESTYLES
Having come from a generation where pills were considered the cure-all , it took a lot of re-programming before I could consider safer options for managing pain and muscle aches. An active lifestyle entails the usually aches and tightness, which means finding remedies that are safe and effective. This is especially true following intense workouts, which often keeps us from performing at our optimum.
VAAY CBD Bath Bomb
A hot bath and massage restores the body and helps ease muscles after a tough workout. Ever wonder why high performance athletes take hot baths after a grueling match or game? Research has found that hot baths significantly improve blood pressure and arterial flow. Studies have also led to the conclusion that hot baths boost immunity, which is often compromised when we engage in heavy exercise. VAAY’s CBD BATH BOMB is a new self care essential that you can indulge in once to twice each week. This fragrant lavender and Shea butter bomb, infused with CBD, instantly melts away the stresses, aches and tension of a long week. I enjoy CBD baths on Friday nights, sometimes pairing it with a glass of wine and relaxing music. It sets the mood for a weekend of relaxation and recovery. The team behind the Berlin-based CBD brand suggests: “For maximum benefits, massage the nurturing center over yourself, using your body heat to activate the CBD and absorb into your skin.”
VAAY CBD Skin and Massage Oil
Following a soak, gently massage VAAY CBD Skin and Massage Oil in circular motions for the sweetest slumber. Evening oil massages have become especially important in the past months with most of our days spent hunched over laptops, mobile phones and adjusting to a work from home set up. This CBD Massage Oil, infused with 200mg of natural CBD, immediately soothes tired muscles. It signals the body that it is time for rest, lulling senses into a deep, undisturbed sleep. Skin is also visibly smoother and radiant the morning after. This is thanks to a potent blend of jojoba, almond oil and ginger essence.
If you seek an extra boost for aches and pains, VAAY’s Active and Sports Gel is a serious miracle worker. A powerful concoction of essential oils and full spectrum CBD first cools tight muscles and tissues. A few seconds after applying a thin layer, a subtle warmth will relax body, mind and soul. It works especially well after an intense run, spin class or core workout. I recently returned to Pilates and manage to survive a killer core workout with VAAY.
THE FEELIST Do Not Disturb Extra Strength Body Cream
On days when I feel heavy and bloated (read: PMS), THE FEELIST DO NOT DISTURB EXTRA STRENGTH BODY CREAM is a heaven sent. It used to be the before and during the monthly cycle, women are unable to move and function at their best. This rich blend of essential oils, natural extracts and 500mg broad spectrum CBD, helps with the discomfort and eases inflammation. DO NOT DISTURB is also a beautiful post-workout recovery elixir that relaxes, restores and brings body back to balance and overall wellbeing.
MADE BY ATHLETES FOR ATHLETES
A CBD brand made by professional athletes for high performance individuals also just recently entered my radar. In the world of sports, THC is a banned substance, which was a challenge for many athletes hoping to get relief from CBD. This inspired two professional athletes to create CBD blends that were safe, suitable and free from any THC. It also saw the birth of PURE SPORT.
The UK-based brand distinguishes itself through blends that are suitable for professional sports. Co Founder Grayson Hart explains: “CBD in the UK is still largely unregulated, so there are a lot of products out there that are hit and miss, weak or contaminated and far from medical grade. We’re in this to convince the world that there is a safe, natural solution to help people feel and live better.” Products from the company undergo rigid testing by two separate third-party companies to guarantee that products are absolutely THC free.
PURE SPORT Boost CBD OIl
Pure Sport’s BOOST is a powerful blend that combines 1500mg CBD, Lions Mane, Ginseng and Vitamin C to enhance energy, brain and immune function. It is also a good anti inflammatory and antioxidant. Adam Ashe, Co Founder of the company, adds, “CBD is best used longer term for treatment of pain. It can cause change in our perception of chronic pain by toning our nervous system over time. This can result in subtle changes in the way we feel pain.”
PURE SPORT CBD Clarity Oil
For pixel sharp focus, Pure Sport’s CLARITY is a brilliant blend that helps to reduce stress and brain fog. It infuses 1500mg CBD with goodness from Ashwangandha, Vitamin D and Gingko Biloba. The founders of the company advice, “We recommend this especially during winter months, as the oil will provide your body and mind with much-needed Vitamin D.”
AN UNAPOLOGETIC CBD BRAND FOR THE BEAUTY JUNKIE
The use of cannabidoil as the main ingredient for beauty products has been around for sometime now. Unlike other brands that rely heavily on advertising, CBD beauty brands are picking up traction on the sole basis that they actually deliver on the promise. Skin was barely recovering from a nasty breakout when a bottle of CBD face oil came to the rescue. Within days, redness and inflammation had disappeared. More than that, texture and tone of skin surface had also dramatically improved. I’ve since become a believer in CBD infused beauty products.
MURI LELU CBD Serum and Night Oils
While most beauty brands use extracts from seeds, MURI LELU harnesses the entire cannabis sativa plant—seeds, stalks and blooms. According to the founders of the brand, this is their skincare secret, “an underutilized anti-inflammatory, antioxidant, anti-aging powerhouse.” Formulation are plant-based, hand crafted and blended with botanicals and terpene-rich oils. They advice: “When looking to try cannabis in your beauty routine for the first time, there are a few things to look for, but the first should be if the cannabis sativa (hemp) extract included in the product is either full spectrum or full flower. This indicates that the widest range of cannabinoids — aka the 80+ therapeutic compounds present in the plant — has been preserved. Full spectrum offers the most potent relief and benefit potential.”
BLOOMRISE SATIVA is a unique facial serum hand-crafted using full spectrum hemp oil. It is specifically formulated so that each drop holds the benefits of the entire sativa plant—phytocannabidoils, terpenes, chlorophyll, flavonoids and fatty acids. The infusion of botanicals and essential oils enhances skin radiance and improves texture. It is a daily dose of skin boost packed with anti inflammation, anti-aging and antioxidant benefits.
For a minimalist, efficient nightly skincare ritual, MAUVAISE HERBE INDICA OIL brings healing properties of the cannabis bloom to relax, restore and refresh skin. This high-performance facial oil calms, balances and restores skin while you sleep. It is a soothing elixir that nourishes so that you wake up to healthier, radiant and youthful skin. For optimum results, massage two to three drops onto the face in upward motions. You may also use your face roller or gua sha to allow for the oils to penetrate.
Beginner’s Guide to CBD
Project CBD has created a beginner’s guide to address key questions people have when starting CBD and cannabis therapy.
Project CBD was established in 2010 by journalists who had been covering the medical marijuana story — the science, the movement and the industry. We felt that the reintroduction of CBD -rich cannabis into the grassroots supply merited special attention. The serendipitous reappearance of whole plant CBD in Northern California in 2009 has given doctors and patients a unique opportunity to evaluate the effects of cannabidiol. Project CBD updates doctors and patients on developments in cannabis science, therapeutics and political economy.
What is CBD?
CBD is a non-intoxicating part of the cannabis plant with enormous healing potential. Although CBD doesn’t make people feel high, it’s causing quite a buzz.
CBD Oil: An Introduction
Medical patients swear by it. Researchers are intrigued by it. Government regulators are flustered by it. And investors are head over heels for it. But what exactly is CBD oil?
10 Tips for Buying CBD
Look for products with clear labels showing the quantity and ratio of CBD and THC per dose, a manufacturing date, and a batch number (for quality control). Select products with quality ingredients that are lab tested and safely extracted.
There is no single ratio or strain that’s right for everyone. A person’s sensitivity to THC is a key factor in determining the appropriate ratio and dosage of CBD -rich medicine. You need to find the combination of CBD and THC that works best for you.
Cannabis Versus Hemp
Compared to whole plant CBD -rich cannabis, industrial hemp grown for fiber or seed is typically low in cannabinoid content. If you live in a state where medical marijuana is legal and available, look for CBD products made from cannabis.
Best Way to Take CBD
Cannabis and CBD oil can be taken in an astounding number of ways. Finding the ideal method for you may take some experimentation.
Is “Pure” CBD Better?
Scientific studies have established that synthetic, single-molecule CBD has a narrow therapeutic window and requires high doses for efficacy as compared to whole-plant, cannabis-derived CBD .
CBD & THC: Myths and Misconceptions
CBD and THC are the power couple of cannabis therapeutics, interacting to amplify one another’s curative properties. CBD enhances THC ’s painkilling and anticancer properties, while lessening THC ’s psychoactivity.
CBD Drug Interactions: What You Need to Know
CBD is a very safe substance, but it can interact with many common pharmaceuticals. At sufficient dosages, CBD will deactivate cytochrome P450 enzymes, thereby altering how we metabolize painkillers, statins, blood thinners, insulin, and other drugs.
CBD User’s Guide
Many health professionals have little to no experience with cannabis therapeutics and are not able to guide people on this subject. So Project CBD has created a beginner’s guide to cannabidiol & cannabis therapeutics to address key questions of CBD users.