Zhang, J. C. [Preliminary report on the serum level of pancreatic polypeptide in patients with chronic bronchitis and bronchial asthma during attacks]. Zhonghua Jie.He.He.Hu Xi.Za Zhi. 1989;12(3):141-2, 190. View abstract.
Rissech, Payret M. and Garcia, Tornel S. [Datura stramonium poisoning]. Med.Clin.(Barc.) 11-25-1979;73(9):397. View abstract.
Boumba, V. A., Mitselou, A., and Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Vet.Hum.Toxicol. 2004;46(2):81-82. View abstract.
Report Problems to the Food and Drug Administration
Tiongson, J. and Salen, P. Mass ingestion of Jimson Weed by eleven teenagers. Del.Med.J 1998;70(11):471-476. View abstract.
Jimson weed is UNSAFE when taken by mouth or inhaled. It is poisonous and can cause many toxic effects including dry mouth and extreme thirst, vision problems, nausea and vomiting, fast heart rate, hallucinations, high temperature, seizures, confusion, loss of consciousness, breathing problems, and death. The deadly dose for adults is 15-100 grams of leaf or 15-25 grams of the seeds.
Despite serious safety concerns, jimson weed is used to treat asthma, cough, flu (influenza), swine flu, and nerve diseases.
Constipation: Jimson weed might cause constipation.
The potential therapeutic aspects of Datura’s psychoactive qualities have not been steadfastly researched, but the plant does have a place in mainstream medicine. Datura has long been used as an anti-inflammatory, a respiratory decongestant, a painkiller, a sleeping aid and more. It also has the potential to offer researchers a deeper understanding of Alzheimer’s.
 Arulvasu, C. et al. (2010). Anti-Cancer Effect of Datura innoxia P. Mill. Leaf Extract in vitro through Induction of Apoptosis in Human Colon Adenocarcinoma and Larynx Cancer Cell Lines. Journal of Pharmacy Research, 3(7), 1485-1488.
 Leavitt, J. W. (1980). Birthing and Anesthesia: The Debate over Twilight Sleep. Signs, 6(1), 147-164.
It’s a good idea to abstain from all other substances for at least a couple of weeks before and after taking Datura.
This “normalcy” is especially true of Datura-induced hallucinations, which can appear perfectly usual, even if they’re totally out of context. Inanimate objects are known to start talking, and the unexpected appearance of absent friends and family is common. Indistinguishable from real people, these entities may just stand and stare at you without saying a word, or they might start a lively conversation with you.   Most people don’t realize they’ve been talking to themselves until they look away for a second and the apparition disappears.    
Datura is a flowering plant often used in ornamental gardens for the beautiful pastel trumpet-shaped flowers it produces. Datura is the genus with between nine and twelve species under its umbrella. As part of the nightshade family, it has been part of religious and cultural rituals for thousands of years, especially in ancient Chinese medicine. The plants grow to about three feet tall all over the world in tropical and moderate climates. Datura seeds develop inside a capsule covered in spines; as it ripens, it splits open and distributes the sees onto the ground.
Also known as Jimson Weed, moonflower, devil’s weed, or thornapple, Datura is a poisonous plant that is unfortunately often abused in recreational use because it produces hallucinations and intoxication that can last for days. Users may ingest the Datura, smoke it, or use it as a lotion on the skin. Sadly, many people die of Datura overdoses because it is so easy to misjudge how much of the drug you’re taking. As little as 15 grams of Datura, which is between 15 and 25 seeds, can be a fatal dose. The side effects on the body can last long after the “high” wears off.
Treating overdose usually involves using activated charcoal to prevent absorption of the drugs and intravenous physostigmine to cross the blood-brain barrier and calm aggravated receptors. However, this antidote cannot be administered to those with heart problems and may only work temporarily, which is another reason that Datura overdose is so dangerous.
What Are Some of the Effects of Datura?
Mentally, Datura can cause amnesia, confusion, psychosis, and hallucinations, in addition to altering mood and emotional expression. If a person takes too much Datura but not enough to overdose, the consumer may still experience something similar to a hangover as the drug metabolizes. The individual may feel some anxiety, dehydration, sleepiness, and light sensitivity, as well as other symptoms.
When these three chemicals are used separately under the supervision of a medical professional, side effects are controlled, and the drugs are generally safe. However, when used in combination as in Daturas, they are very dangerous and easy to overdose. The signs of an overdose include an inability to tell reality from fantasy, high body temperature, tachycardia, violent behavior, and pupil dilation.
Three chemicals, hyoscyamine, atropine, and scopolamine, give Datura its intoxicating and medicinal properties.