Wilhelm, H., Wilhelm, B., and Schiefer, U. [Mydriasis caused by plant contact]. Fortschr.Ophthalmol. 1991;88(5):588-591. View abstract.
Calbo Mayo, J. M., Barba Romero, M. A., Broseta, Viana L., and Medrano, Gonzalez F. [Accidental familiar poisoning by Datura stramonium]. An.Med.Interna 2004;21(8):415. View abstract.
Dessanges, J. F. A history of nebulization. J Aerosol Med. 2001;14(1):65-71. View abstract.
Report Problems to the Food and Drug Administration
Osvath, P., Nagy, A., Fekete, S., Tenyi, T., Trixler, M., and Radnai, I. [A case of datura stramonium poisoning–general problems of differential diagnosis]. Orv.Hetil. 1-16-2000;141(3):133-136. View abstract.
Toxic megacolon: In this life-threatening condition, the large intestine (colon) suddenly becomes extra wide because of an infection or other intestinal disorder. Taking jimson weed might make this condition worse.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Munzert, E., Heidemann, R., Buntemeyer, H., Lehmann, J., and Muthing, J. Production of recombinant human antithrombin III on 20-L bioreactor scale: Correlation of supernatant neuraminidase activity, desialylation, and decrease of biological activity of recombinant glycoprotein. Biotechnol Bioeng. 11-20-1997;56(4):441-448. View abstract.
Jimson weed (Datura stramonium, a member of the Belladonna alkyloid family) is a plant growing naturally in West Virginia and has been used as a home remedy since colonial times. Due to its easy availability and strong anticholinergic properties, teens are using Jimson weed as a drug. Plant parts can be brewed as a tea or chewed, and seed pods, commonly known as “pods” or “thorn apples,” can be eaten. Side effects from ingesting jimson weed include tachycardia, dry mouth, dilated pupils, blurred vision, hallucinations, confusion, combative behavior, and difficulty urinating. Severe toxicity has been associated with coma and seizures, although death is rare. Treatment consists of activated charcoal and gastric lavage. Esmolol or other beta-blocker may be indicated to reduce severe sinus tachycardia. Seizures, severe hypertension, severe hallucinations, and life-threatening arrhythmias are indicators for the use of the anticholinesterase inhibitor, Physostigmine. This article reviews the cases of nine teenagers who were treated in hospitals in the Kanawha Valley after ingesting jimson weed. We hope this article will help alert primary care physicians about the abuse of jimson weed and inform health officials about the need to educate teens about the dangers of this plant.
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